Dynamic 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (dFDG-PET) for human brain imaging has considerable clinical potential, yet its utilization remains limited. A key challenge in the quantitative analysis of dFDG-PET is characterizing a patient-specific blood input function, traditionally reliant on invasive arterial blood sampling. This research introduces a novel approach employing non-invasive deep learning model-based computations from the internal carotid arteries (ICA) with partial volume (PV) corrections, thereby eliminating the need for invasive arterial sampling. We present an end-to-end pipeline incorporating a 3D U-Net based ICA-net for ICA segmentation, alongside a Recurrent Neural Network (RNN) based MCIF-net for the derivation of a model-corrected blood input function (MCIF) with PV corrections. The developed 3D U-Net and RNN was trained and validated using a 5-fold cross-validation approach on 50 human brain FDG PET datasets. The ICA-net achieved an average Dice score of 82.18% and an Intersection over Union of 68.54% across all tested scans. Furthermore, the MCIF-net exhibited a minimal root mean squared error of 0.0052. The application of this pipeline to ground truth data for dFDG-PET brain scans resulted in the precise localization of seizure onset regions, which contributed to a successful clinical outcome, with the patient achieving a seizure-free state after treatment. These results underscore the efficacy of the ICA-net and MCIF-net deep learning pipeline in learning the ICA structure's distribution and automating MCIF computation with PV corrections. This advancement marks a significant leap in non-invasive neuroimaging.

We introduce OpenEarthMap, a benchmark dataset, for global high-resolution land cover mapping. OpenEarthMap consists of 2.2 million segments of 5000 aerial and satellite images covering 97 regions from 44 countries across 6 continents, with manually annotated 8-class land cover labels at a 0.25--0.5m ground sampling distance. Semantic segmentation models trained on the OpenEarthMap generalize worldwide and can be used as off-the-shelf models in a variety of applications. We evaluate the performance of state-of-the-art methods for unsupervised domain adaptation and present challenging problem settings suitable for further technical development. We also investigate lightweight models using automated neural architecture search for limited computational resources and fast mapping. The dataset is available at https://open-earth-map.org.